BPR initiatives: The impacts of IT and organisational customs and practices

This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University, 28/02/2002.This research is designed to investigate the relationship between IT and Organisational customs and practices in Business Process Reengineering (BPR) projects based on a research framework, which consists of organisational culture, IT and the outcome of BPR initiatives together with the inextricable interdependence between them. The focus is on developing a process oriented, context-based description and explanation of the BPR phenomenon in Arab Gulf Cooperation Council (AGCC) countries. The study strives to describe and explain the process of adopting and implementing BPR initiatives in petrochemical and utilities industries in AGCC countries in terms of interaction of contextual conditions, actions and consequences. The research methodology of this thesis focuses on the pragmatics of conducting case studies as a rigorous and effective method of research. The study emphasises on conducting positivist inquiry of three case studies' data to deductively test the researcher's understanding on BPR and her assumptions of 'Blueprints' for successful BPR in AGCC countries. Two of the case studies organisations are sister companies operating in the oil and gas industry, whereas the third case study organisation is a utility company operating in the field of water and electricity generation and supply. This study resulted in a framework that could serve as a prescription to achieve a successful BPR initiative. It has identified a number of organisational elements that emphasised the necessity to pay attention to cultural and IT issues prior to undertaking BPR projects. These include the development of strategy and sound stimuli for the project, the availability of leadership, top management vision, availability of required skills and expertise and the maturity of the IT infrastructure. In addition, the study has empirically emphasised a number of BPR project implementation elements that should be in place to ensure successful implementation and management of the project including: the availability of an appropriately composed project team, continuous communication, users' involvement and usage of communication technologies

Flow-Aware Elephant Flow Detection for Software-Defined Networks

Software-defined networking (SDN) separates the network control plane from the packet forwarding plane, which provides comprehensive network-state visibility for better network management and resilience. Traffic classification, particularly for elephant flow detection, can lead to improved flow control and resource provisioning in SDN networks. Existing elephant flow detection techniques use pre-set thresholds that cannot scale with the changes in the traffic concept and distribution. This paper proposes a flow-aware elephant flow detection applied to SDN. The proposed technique employs two classifiers, each respectively on SDN switches and controller, to achieve accurate elephant flow detection efficiently. Moreover, this technique allows sharing the elephant flow classification tasks between the controller and switches. Hence, most mice flows can be filtered in the switches, thus avoiding the need to send large numbers of classification requests and signaling messages to the controller. Experimental findings reveal that the proposed technique outperforms contemporary methods in terms of the running time, accuracy, F-measure, and recall

The Effects of Carbon Emissions and Agency Costs on Firm Performance

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Regression model for the study of sole and cumulative effect of temperature and solar radiation on wheat yield

The effect of variability in temperature, solar radiation and photothermal quotient were studied under varying planting windows in three wheat genotypes to cope environmental vulnerability. Regression models are regarded as valuable tools for the evaluation of temperature, solar radiation and photothermal quotient effects on wheat yield to bring its resilience to climatic vulnerability. The objective of this study was to evaluate sole and cumulative impact of temperature and solar radiation on spring wheat (Triticum aestivum L.) yield using regression modeling approach. The data collected at maturity for grain number, grain weight and grain yield were regressed against mean temperature, solar radiation and photothermal quotient (PTQ) (temperature plus solar radiation) from emergence to anthesis and maturity, using STATISTICA9 software. Scatter-plot regression model was developed at 95% confidence interval with crop data and climate variables. Results indicate direct relationship of yield with solar radiation, cumulative effect of temperature and solar radiation, whereas yield had an inverse relationship with temperature alone. Direct relationship between PTQ and yield parameters confirmed PTQ as crop-yield determinant, thus, its management needs to be done by choosing a more appropriate sowing time and best suited genotypes as an adapted management strategy for farmers under increased climatic vulnerability.Key words: Photothermal quotient, planting windows, solar radiation, temperature, wheat

Role of IL-28B polymorphisms in virologic response to combined pegylated interferon and ribavirin therapy in genotype 4 chronic HCV infected patients with and without cirrhosis

Background: Chronic hepatitis C virus (HCV) represents one of the common causes of chronic liver disease worldwide with Egypt having the highest prevalence, namely genotype 4. The rs12979860 CC genotype of the interleukin 28B (IL28B) polymorphisms is associated with high rates of sustained virological response to pegylated interferon and ribavirin in HCV genotype-1 patients. Data on other genotypes are more limited.Objective: We aim to evaluate the predictive power of the rs12979860 IL28B single nucleotide  polymorphisms for treatment response at 3 and 6 months in chronic HCV genotype 4 Egyptian patients in relation to other predictors.Patients and methods: The study included 60 chronic HCV Egyptian patients receiving pegylated interferon and ribavirin therapy. Patients were classified into 2 groups; 30 patients with compensated cirrhosis, and 30 patients without cirrhosis. We analyzed selected pretreatment factors such as age, sex, HCV viral load, anti-schistosomal antibodies, insulin resistance, alpha fetoprotein, low and high density lipoproteins and single nucleotide polymorphisms of IL28B and tried to find out which of them influence sustained virological response.Results: In univariate analysis, CC genotype showed a significant association with sustained virological response at 6 months among the cirrhotic patients (81.8% responders had the CC genotype, 58.3% had the CT/TT genotype) (p= 0.009). While in multivariate analysis, the presenceKEYWORDS: HCV; IL28B; Polymorphism; Interferon; Schistosomiasis; Respons

Synthesis, structural analysis, electrochemical and magnetic properties of tetrachloroferrate ionic liquids

Eight ionic liquids have been synthesized with the tetrachloroferrate anion and varying cations with the general formula of [RA]+[FeCl4]− (R = –CH3, –CH2C6H5; A = pyridine, benzimidazole, trimethylamine, triphenylphosphine). They were characterized using spectroscopic techniques such as FT-IR, ESI-MS, Raman, and AAS along with single-crystal XRD to validate their structural motifs. The ionic conductivity, electrochemical and magnetic properties were determined to assess their possible uses in synthesis, separation, magnetic and transportation technologies, and high-energy capacitors. The diffusion coefficient value for these compounds was calculated to be around 7.55 × 10−8 cm2 s−1 and the heterogeneous rate constant value is about 3.60 × 10−3 cm s−1, which quantitatively complemented not only quasi reversibility but also moderately fast electron transfer processes. The effective magnetic moment values for the ionic liquids were determined to be similar to that expected from the spin-only approximation

A novel A781V mutation in the CSF1R gene causes hereditary diffuse leucoencephalopathy with axonal spheroids

We report a family with a novel CSF1R mutation causing hereditary diffuse leucoencephalopathy with axonal spheroids. Family members presented with neuropsychiatric and behavioural symptoms, with subsequent development of motor symptoms and gait disturbance. MRI brain showed extensive white matter change with a frontal predominance and associated atrophy in two members of the family. Genetic testing revealed a novel mutation c.2342C>T (p.A781V) in the CSF1R gene in two brothers of the family. This report highlights the difficulties in diagnosing HDLS and discusses the indications for testing for mutations in the CSF1R gene

Respiratory effects of propofol-ketamine and propofl-fentanyl combinations for total intravenous anaesthesia

propofol combined with other intravenous analgesic agents has been used as the sole anaesthetic agent to provide hypnosis and analgesia for various minor and major surgeries. However, because it lacks analgesic property, propofol in large doses causes respiratory depression. Combination of propofol with other analgesic agents reduces the dose of propofol necessary for procedural sedation. Objectives: This study evaluated the respiratory effects of two drug combinations: propofol-ketamine and propofol-fentanyl used as the sole anaesthetic agents. Method: one hundred and eight adults aged 18 to 50 years of either gender with ASA physical status I & II, randomly grouped into K and F, comprising of 54 patients each. Group K received propofol-ketamine while group F received propofol-fentanyl for induction and maintenance of anaesthesia. Respiratory Rate (RR) and Oxygen saturation (SpO were recorded before and one 2) minutes after induction of anaesthesia and thereafter every five minutes till the end of procedure and at recovery till the patient is fully recovered. Results: Demographic and clinical characteristics such as age, sex, weight, duration of surgery, types of surgical procedures and volumes of drugs used were comparable between the two groups. Fall in respiratory rate was greater in propofol-fentanyl group compared to propofol-ketamine group during maintenance and early postoperative period (p<0.05). Conclusion: Both propofol-ketamine and propofolfentanyl combinations produced safe and effective anaesthesia. Propofol-ketamine results in a more stable respiratory profile

Synergistic Antimicrobial Activities Of Phytoestrogens In Crude Extracts Of Two Sesame Species Against Some Common Pathogenic Microorganisms

Intensive studies on extracts and biologically active compounds isolated from medicinal plants have doubled in the last decade worldwide. However, as a result of paucity of knowledge and folkloric claim on the effectiveness of sesame leaves in infectious disease treatments, we aimed to determine the synergistic antimicrobial activity of essential oils and lignans present in the crude leaves extracts of Sesame radiatum and Sesame indicum. Ethanolic, methanolic and aqueous extracts of both leaves were studied for their in-vitro synergistic antimicrobial activity against both Gram positive and Gram negative micro-organisms, and Yeast using Agar diffusion method. The GC-MS phytochemical screening of methanolic extract showed that the major compounds in essential oils are of carboxylic acids and phenolic groups especially, the most potent antioxidants known to man like sesamol, sesamolin and sesamin among others. Methanolic and ethanolic extracts have broad spectrum antimicrobial effect against all the tested pathogenic micro-organisms except Streptococcus pneumoniae and Staphylococcus aureus respectively, while the aqueous extract exhibited inhibitory activity on Staphylococcus aureus, Streptococcus pneumoniae and Candida albicans. The result confirmed the folkloric claims of the antimicrobial effectiveness of locally consumed sesame leaves extracts especially against bacterial and common skin infection in many areas of Nigeria . Keywords: Pathogenic micro-organisms, Gram-positive, Gram-negative,Yeast, Anti-microbial, Sesame leaves, GC-MS, MICAfrican Journal of Traditional and Complementary Medicine Vol. 4 (4) 2007: pp. 427-43

Microbiological Quality of some Expired Drugs in Sokoto Metropolis, Nigeria

Twenty eight samples of expired drugs were obtained from different medical stores including Sokoto State Medical Store in Sokoto Metropolis. The drugs included paracetamol, vitamin C (Ascorbic acid), Phenergan (promethazine), Chloroquine (A 4–aminoquinoline acid), flagyl (metronidazole), folic acid (Pteroylglutamic acid), tablets and vitamin A injection (Retinol). The tablets were ground into powder using sterile pestle and mortar. Powder of each tablet (0.2g) and 0.2ml vitamin A injection was dispensed into 9ml sterile nutrient broth. After incubation for 24 hours, a loopful from the growth was subcultured into nutrient agar and malt extract agar plates. The nutrient agar plates were incubated at 37oC for 24 hours and the Malt Extract plates were incubated at 26oC for 3-7 days After incubation, the organisms were identified using a combination of microscopy and biochemical tests. For each drug, the procedure was repeated four times. The frequency of occurrence of each organism was determined and found to be: Aspergillus niger 28(60%); Aspergillus flavus 28(32%); Penicillium spp. 28(14%); Scopulariopsis spp. 28(7%); Neurospora spp. 28(7%); Mucor sp. 28(4%); Enterococcus avium 28(35%); Staphylococcus aureus 28(29%); Enteococcus gallinarum 28(25%); Staphylococcus epidermidi, 28(17%); Enterococcus durans 28(14%) and Staphylococcus saccharolyticus 28(14%). The results demonstrated the involvement of pathogenic microorganisms; therefore, expired drugs should not be consumed no matter how neat they may appear